The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Statins, which are competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A
reductase, reduce cholesterol blood levels and the risk of developing cardiovascular …

According to clinical studies, statins improve the efficacy of programmed death-
1/programmed death-ligand 1 (PD-1/PD-L1) blockade therapy for breast cancer; however …

Background: Studies suggest that obesity is associated with lower risk of prostate cancer but
more aggressive cancers. As obesity lowers PSA levels, these observations may be …

An increasing amount of data supports an inverse association between statin use and
cancer risk. The findings for prostate cancer, particularly advanced disease, are the most …

Importance Statin use has been associated with improved prostate cancer outcomes.
Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and a substrate for …

Background Epidemiologic evidence for a serum cholesterol-prostate cancer link is mixed.
Prostate-specific antigen (PSA) is positively correlated with cholesterol, potentially …

Objective The objective of the French Urology Association Cancer Committee is to propose
an update of the recommendations for the diagnosis and management of prostate cancer …

Background: Coronary artery disease (CAD) and prostate cancer (PCa) are not only
common diseases, but share many risk factors. To date, only a few studies have explored …

Background Prostate cancer is a common cancer but is oftentimes slow growing. When
confined to the prostate, radical prostatectomy (RP), which involves removal of the prostate …