There is a distinct increase in the risk of heart disease in people exposed to ionizing
radiation (IR). Radiation‐induced heart disease (RIHD) is one of the adverse side effects …

Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce
apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …

An optimal radiosensitizer with improved tumor retention has an important effect on tumor
radiation therapy. Herein, gold nanoparticles (Au NPs) and drug‐containing, mPEG …

Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and
autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial …

Immune system interactions within the tumour have a key role in the resistance or
sensitization of cancer cells to anti-cancer agents. On the other hand, activation of the …

Radiation‐induced myocardial fibrosis (RIMF) is a potentially lethal clinical complication of
chest radiotherapy (RT) and a final stage of radiation‐induced heart disease (RIHD). RIMF is …

Reactive oxygen species (ROS) are ubiquitous metabolic products and important cellular
signaling molecules that contribute to several biological functions. Pathophysiology arises …

Opinion statement Cancer patients who receive high-dose thoracic radiotherapy may
develop radiation-induced heart disease (RIHD). The clinical presentation of RIHD …

Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …