The PIM kinase, also known as serine/threonine kinase plays an important role in cancer
biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are …

Cytosolic PIM kinases are the members of serine/threonine family play a crucial role in the
cancer progression and development. Overexpression of PIM kinases is observed in various …

A series of pyridine and thieno [2, 3-b] pyridine derivatives have been designed and
synthesized as anticancer PIM-1 kinase inhibitors. Thirty-seven compounds were selected …

In this research article, Zr-MOFs based copper complex as a novel heterogeneous and
porous catalyst was designed and prepared. The structure of catalyst has verified by various …

Herein, we report design and synthesis of twenty-one dual PIM-1/HDAC inhibitors utilizing 3-
cyanopyridines as a novel cap moiety linked with aliphatic/aromatic linker bearing carboxylic …

Recently, inhibition of PIM-1 enzyme is found as an effective route in the fight against
proliferation of cancer. Herein, new cyano pyridines that target PIM-1 kinase were designed …

New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase
inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low cytotoxicity against …

The successful evolution of an effective drug depends on its pharmacokinetics, efficiency
and safety and these in turn depend on the drug-target/drug-carrier protein binding. This …

Pyridines have occupied a unique place in medicinal chemistry as it is widely profound as
natural products and formed the integral backbone of great number of drugs in the market. In …

New hybrids of tetralin‐pyrazolo [3, 4‐b] pyridine were synthesized in good yields. The
structures of newly synthesized compounds were confirmed by IR, NMR, MS, and elemental …