Current and emerging pharmacological targets and treatments of urinary incontinence and related disorders

MC Michel, L Cardozo, CJ Chermansky, F Cruz… - Pharmacological …, 2023 - ASPET
Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

P2X3-containing receptors as targets for the treatment of chronic pain

JL Krajewski - Neurotherapeutics, 2020 - Springer
Current therapies for the treatment of chronic pain provide inadequate relief for millions of
suffering patients, demonstrating the need for better therapies that will treat pain effectively …

Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

Development of a dynamic nomogram for predicting the probability of satisfactory recovery after 6 months for cervical traumatic spinal cord injury

X Yan, Y He, M Jia, J Yang, K Huang… - Orthopaedic …, 2023 - Wiley Online Library
Objective Cervical traumatic spinal cord injury (CTSCI) is a seriously disabling disease that
severely affects the physical and mental health of patients and imposes a huge economic …

Continuous administration of leuprolide acetate improves urinary function in male rats with severe thoracic spinal cord injury

JL Palacios, S Luquin, JL Quintanar, A Munoz - Life Sciences, 2022 - Elsevier
Aims To determine if a continuous administration of leuprolide acetate (LA), a synthetic
agonist for the gonadotrophin-releasing hormone receptor, facilitates the recovery of urinary …

Posterior tibial nerve stimulation improves neurogenic bladder in rats with spinal cord injury through transient receptor potential/P2X signaling pathway

J Song, X Cao, A Zhang, Z Fang, J Xu… - Neurourology and …, 2022 - Wiley Online Library
Background To study the influences of posterior tibial nerve stimulation (PTNS) on
neurogenic bladder and the expression of transient receptor potential (TRP) channels and …

Therapeutic effects and modulatory mechanism of Alpiniae oxyphyllae Fructus in chronic intermittent hypoxia induced enuresis in rats

MS Su, L Xu, SG Gu, N Huang, XK Ren, XH Cai… - Sleep and …, 2020 - Springer
Objective The objective of this study was to explore the effect of Alpiniae oxyphyllae Fructus
(AOF) on a rat model of chronic intermittent hypoxia (CIH)–induced enuresis. Findings of this …

[HTML][HTML] Urinary ATP may be a biomarker of interstitial cystitis/bladder pain syndrome and its severity

Y Wu, Y He, J Qi, S Wang, Z Wang - Biomolecules and Biomedicine, 2024 - ncbi.nlm.nih.gov
Urinary tract cells respond to bladder distension by releasing adenosine triphosphate (ATP).
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) exhibit elevated urinary ATP …

Choice of cystometric technique impacts detrusor contractile dynamics in wistar rats

D Medina‐Aguinaga, RF Hoey, A Munoz… - Physiological …, 2021 - Wiley Online Library
The objective of the current animal study was to investigate factors contributing to the
different phases of the cystometrogram (CMG) in order to address disparities in research …

[Retracted] Outcomes of Patients with Cervical Spinal Cord Injury Treated by Surgery and Their Prognostic Factors

X Wu, Q Song, P Jin, B Liu - Applied Bionics and Biomechanics, 2022 - Wiley Online Library
Objective. To investigate the outcomes of patients with cervical spinal cord injury treated by
surgery and their prognostic factors. Methods. We retrospectively analyzed 139 patients with …