Until recently most studies of metastasis only measured the end point of the process—
macroscopic metastases. Although these studies have provided much useful information …

Prostate cancer is one of the most frequently diagnosed malignancies in developed
countries and approximately 248,530 new cases of prostate cancer are likely to be …

Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a
strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that …

Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been
targeted with RNA aptamer–small interfering (si) RNA chimeras, but therapeutic efficacy in …

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor due to the lack of
effective therapeutic drugs. Cancer therapy targeting programmed cell death protein 1 (PD …

During metastasis, cancer cells enter the circulation in order to gain access to distant
tissues, but how this fluid microenvironment influences cancer cell biology is poorly …

During metastasis, cancer cells are exposed to potentially destructive hemodynamic forces
including fluid shear stress (FSS) while en route to distant sites. However, prior work …

Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate
therapeutic strategies that improve clinical outcomes. We used experimental models and …

Lysyl oxidase (LOX), an extracellular matrix remodeling enzyme, appears to have a role in
promoting breast cancer cell motility and invasiveness. In addition, increased LOX …

Metastatic colonization involves cancer cell lodgment or adherence in the microvasculature
and subsequent migration of those cells across the endothelium into a secondary organ site …