Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Background Human mesenchymal stem cell (hMSC) differentiation into osteoblasts has
important clinical significance in treating bone injury, and the stiffness of the extracellular …

The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …

In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct
skeletal stem cell (SSC) commitment and differentiation. However, the mechanisms by which …

The emergence of collagen I in vertebrates resulted in a dramatic increase in the stiffness of
the extracellular environment, supporting long-range force propagation and the …

Osteogenesis imperfecta, or brittle bone disease, is a congenital disease that primarily
causes low bone mass and bone fractures but it can negatively affect other organs. It is …

Although the link between altered stem cell properties and tissue aging has been
recognized, the molecular and cellular processes of tendon aging have not been elucidated …