X chromosome regulation: diverse patterns in development, tissues and disease
X Deng, JB Berletch, DK Nguyen… - Nature Reviews …, 2014 - nature.com
Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
Dosage compensation of the sex chromosomes
CM Disteche - Annual review of genetics, 2012 - annualreviews.org
Differentiated sex chromosomes evolved because of suppressed recombination once sex
became genetically controlled. In XX/XY and ZZ/ZW systems, the heterogametic sex became …
became genetically controlled. In XX/XY and ZZ/ZW systems, the heterogametic sex became …
Dosage compensation of the sex chromosomes and autosomes
CM Disteche - Seminars in cell & developmental biology, 2016 - Elsevier
Males are XY and females are XX in most mammalian species. Other species such as birds
have a different sex chromosome make-up: ZZ in males and ZW in females. In both types of …
have a different sex chromosome make-up: ZZ in males and ZW in females. In both types of …
Trm9-catalyzed tRNA modifications regulate global protein expression by codon-biased translation
Post-transcriptional modifications of transfer RNAs (tRNAs) have long been recognized to
play crucial roles in regulating the rate and fidelity of translation. However, the extent to …
play crucial roles in regulating the rate and fidelity of translation. However, the extent to …
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals
In mammals, X-chromosomal genes are expressed from a single copy since males (XY)
possess a single X chromosome, while females (XX) undergo X inactivation. To compensate …
possess a single X chromosome, while females (XX) undergo X inactivation. To compensate …
The spectrum of CHM gene mutations in choroideremia and their relationship to clinical phenotype
Purpose: We report the underlying genotype and explore possible genotypic-phenotypic
correlations in a large cohort of choroideremia patients. Methods: We studied prospectively …
correlations in a large cohort of choroideremia patients. Methods: We studied prospectively …
[HTML][HTML] Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation
X upregulation in mammals increases levels of expressed X-linked transcripts to
compensate for autosomal biallelic expression. Here, we present molecular mechanisms …
compensate for autosomal biallelic expression. Here, we present molecular mechanisms …
[HTML][HTML] TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185
F Qiu, JP Xiong, J Deng, XJ Xiang - International journal of clinical …, 2015 - ncbi.nlm.nih.gov
Abstract Tripartite motif-containing 29 (TRIM29) belongs to TRIM family of transcription
factors and may function as an oncogene or a tumor suppressor depending on the tumor …
factors and may function as an oncogene or a tumor suppressor depending on the tumor …
Epigenetics drive the evolution of sex chromosomes in animals and plants
We review how epigenetics affect sex chromosome evolution in animals and plants. In a few
species, sex is determined epigenetically through the action of Y-encoded small RNAs …
species, sex is determined epigenetically through the action of Y-encoded small RNAs …
Non-canonical and sexually dimorphic X dosage compensation states in the mouse and human germline
MN Sangrithi, H Royo, SK Mahadevaiah, O Ojarikre… - Developmental cell, 2017 - cell.com
Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene
output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno …
output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno …