Preferentially expressed antigen in melanoma is a multifaceted cancer testis antigen with diverse roles as a biomarker and therapeutic target

M Bose - International Journal of Translational Medicine, 2023 - mdpi.com
Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) that
is selectively expressed in certain somatic tissues, predominantly in the testis, and is …

The delicate balance of graft versus leukemia and graft versus host disease after allogeneic hematopoietic stem cell transplantation

K Maurer, RJ Soiffer - Expert Review of Hematology, 2023 - Taylor & Francis
Introduction The curative basis of allogeneic hematopoietic stem cell transplantation (HSCT)
relies in part upon the graft versus leukemia (GvL) effect, whereby donor immune cells …

Photothermal Prussian blue nanoparticles generate potent multi‐targeted tumor‐specific T cells as an adoptive cell therapy

EE Sweeney, P Sekhri, N Muniraj… - Bioengineering & …, 2024 - Wiley Online Library
Prussian blue nanoparticle‐based photothermal therapy (PBNP‐PTT) is an effective tumor
treatment capable of eliciting an antitumor immune response. Motivated by the ability of …

Immunotherapy for pediatric acute lymphoblastic leukemia: Recent advances and future perspectives

M Lv, Y Liu, W Liu, Y Xing, S Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Pediatric acute lymphoblastic leukemia (ALL) is the most common subtype of childhood
leukemia, which is characterized by the abnormal proliferation and accumulation of …

PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic Factor in Uveal Melanoma

MC Gelmi, G Gezgin… - … & Visual Science, 2023 - iovs.arvojournals.org
Purpose: Uveal melanoma (UM) is a rare disease with a high mortality, and new therapeutic
options are being investigated. Preferentially Expressed Antigen in Melanoma (PRAME) is a …

Targeting IDH2R140Q and other neoantigens in acute myeloid leukemia

WK Leung, AG Torres Chavez, M French-Kim, P Shafer… - Blood, 2024 - ashpublications.org
For patients with high-risk or relapsed/refractory acute myeloid leukemia (AML), allogeneic
stem cell transplantation (allo-HSCT) and the graft-versus-leukemia effect mediated by …

Current developments in T-cell receptor therapy for Acute Myeloid Leukaemia

S Gore, E Blyth, M Bleakley, K Lee… - Blood …, 2025 - ashpublications.org
T-cell receptor (TCR) therapies are a promising modality for the treatment of cancers, with
significant efforts being directed towards acute myeloid leukaemia (AML), a particularly …

The next horizon now that everyone has a donor: Precision allogeneic transplantation

RJ Jones, A Bacigalupo - Blood Reviews, 2023 - Elsevier
Post-transplant cyclophosphamide (PTCy) allows safe and effective partially matched donor
allogeneic blood or marrow transplantation (alloBMT), so that almost everyone in need of …

Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles

EE Sweeney, P Sekhri, D Telaraja, J Chen, SJ Chin… - Cytotherapy, 2023 - Elsevier
Background Adoptive T cell therapy (ATCT) has been successful in treating hematological
malignancies and is currently under investigation for solid-tumor therapy. In contrast to …

Durable immunity to EBV after rituximab and third-party LMP-specific T cells: a Children's Oncology Group study

B Wistinghausen, K Toner, DA Barkauskas… - Blood …, 2024 - ashpublications.org
Posttransplant lymphoproliferative disease (PTLD) in pediatric solid organ transplant (SOT)
recipients is characterized by uncontrolled proliferation of Epstein-Barr virus–infected …