Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Background Alzheimer's disease is the most prevalent cause of dementia in the elderly.
Neuronal death and synaptic dysfunctions are considered the main hallmarks of this …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

Obesity-linked insulin resistance is a major precursor to the development of type 2 diabetes.
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated …

It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative
diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …

ABSTRACT Cyclin dependent kinase-5 (Cdk5), a family member of the cyclin-dependent
kinases, plays a pivotal role in the central nervous system. During embryogenesis, Cdk5 is …

Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of
the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an …

Neurodegenerative diseases are featured by progressive dysfunction and death of cells in
selected areas in the nervous system, determining clinical presentation. Neuronal loss is …