Targeted therapy for hepatocellular carcinoma

A Huang, XR Yang, WY Chung, AR Dennison… - Signal transduction and …, 2020 - nature.com
The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …

Biomarkers in hepatocellular carcinoma: diagnosis, prognosis and treatment response assessment

F Piñero, M Dirchwolf, MG Pessôa - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death
worldwide. Thus, there is a constant search for improvement in screening, diagnosis, and …

Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma

J Bruix, M Reig, M Sherman - Gastroenterology, 2016 - Elsevier
Evidence-based management of patients with hepatocellular carcinoma (HCC) is key to
their optimal care. For individuals at risk for HCC, surveillance usually involves …

NCCN guidelines insights: Hepatobiliary cancers, version 2.2019: Featured updates to the NCCN guidelines

AB Benson, MI D'Angelica, DE Abbott… - Journal of the National …, 2019 - jnccn.org
The NCCN Guidelines for Hepatobiliary Cancers provide treatment recommendations for
cancers of the liver, gallbladder, and bile ducts. The NCCN Hepatobiliary Cancers Panel …

[PDF][PDF] International Liver Cancer Association (ILCA) white paper on biomarker development for hepatocellular carcinoma

AG Singal, Y Hoshida, DJ Pinato, J Marrero, JC Nault… - Gastroenterology, 2021 - Elsevier
International Liver Cancer Association (ILCA) White Paper on Biomarker Development for
Hepatocellular Carcinoma Page 1 1 International Liver Cancer Association (ILCA) White Paper …

Sorafenib: a review in hepatocellular carcinoma

GM Keating - Targeted oncology, 2017 - Springer
Sorafenib (Nexavar®) is currently the only systemic agent approved for use in hepatocellular
carcinoma (HCC). Its approval was based on the results of the pivotal SHARP and Sorafenib …

Anti-hepatocellular carcinoma biomolecules: molecular targets insights

N Juaid, A Amin, A Abdalla, K Reese, Z Alamri… - International journal of …, 2021 - mdpi.com
This report explores the available curative molecules directed against hepatocellular
carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to …

Liver cancer: approaching a personalized care

J Bruix, KH Han, G Gores, JM Llovet… - Journal of …, 2015 - journal-of-hepatology.eu
The knowledge and understanding of all aspects of liver cancer [this including
hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA)] have …

[HTML][HTML] Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: analysis of two phase III studies

J Bruix, AL Cheng, G Meinhardt, K Nakajima… - Journal of …, 2017 - Elsevier
Background & Aims Sorafenib, an oral multikinase inhibitor, significantly prolonged overall
survival (OS) vs. placebo in patients with unresectable hepatocellular carcinoma (HCC) in …

Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study

A Santoro, L Rimassa, I Borbath, B Daniele… - The lancet …, 2013 - thelancet.com
Summary Background Tivantinib (ARQ 197), a selective oral inhibitor of MET, has shown
promising antitumour activity in hepatocellular carcinoma as monotherapy and in …