Higher-order structure and proteoforms of co-occurring C4b-binding protein assemblies in human serum
The complement is a conserved cascade that plays a central role in the innate immune
system. To maintain a delicate equilibrium preventing excessive complement activation …
system. To maintain a delicate equilibrium preventing excessive complement activation …
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome
S Si, H Liu, L Xu, S Zhan - Genome Medicine, 2024 - Springer
Background Chronic kidney disease (CKD) is a progressive disease for which there is no
effective cure. We aimed to identify potential drug targets for CKD and kidney function by …
effective cure. We aimed to identify potential drug targets for CKD and kidney function by …
Multiomic profiling of new-onset kidney function decline: insights from the STANISLAS study cohort with a 20-year follow-up
V Dupont, C Xhaard, I Behm-Ansmant… - Clinical Kidney …, 2024 - academic.oup.com
Background Identifying the biomarkers associated with new-onset glomerular filtration rate
(GFR) decrease in an initially healthy population could offer a better understanding of kidney …
(GFR) decrease in an initially healthy population could offer a better understanding of kidney …
Proteomics profiling and association with cardiorenal complications in type 2 diabetes subtypes in Asian population
Abstract Aim Among multi-ethnic Asians, type 2 diabetes (T2D) clustered in three subtypes;
mild obesity-related diabetes (MOD), mild age-related diabetes with insulin insufficiency …
mild obesity-related diabetes (MOD), mild age-related diabetes with insulin insufficiency …
Causal association of plasma circulating metabolites with nephritis: a Mendelian randomization study
F Shao, Y Yao, D Weng, R Wang, R Liu, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
Background Nephritis is a pivotal catalyst in chronic kidney disease (CKD) progression.
Although epidemiological studies have explored the impact of plasma circulating …
Although epidemiological studies have explored the impact of plasma circulating …
[PDF][PDF] Integrated Proteomic and Metabolomic Modules associated with Risk of Kidney Disease Progression
Background: Proteins and metabolites play crucial roles in various biological functions and
are frequently interconnected through enzymatic or transport processes. Methods: We …
are frequently interconnected through enzymatic or transport processes. Methods: We …
Blood Proteomics for Biomarkers of Kidney Pathology
A Beenken, K Kiryluk - Journal of the American Society of …, 2024 - journals.lww.com
Biomarkers have particular utility when they can direct clinical care to avoid invasive
diagnostic or therapeutic procedures, such as a kidney biopsy. Discovery of novel …
diagnostic or therapeutic procedures, such as a kidney biopsy. Discovery of novel …
[PDF][PDF] Investigating Kidney Disease Clinical Epidemiology Using Routinely Collected Administrative Data and Proteomics
RE Aylward - 2024 - research-information.bris.ac.uk
Data collected routinely during healthcare visits and additional biospecimens collected as
part of cohort study activities are invaluable to better understand kidney disease …
part of cohort study activities are invaluable to better understand kidney disease …
[引用][C] Aptamer-Based Proteomics in CKD
T Kim, EP Rhee - American Journal of Kidney Diseases, 2024 - ajkd.org
Commentary on: Dubin RF, Deo R, Ren Y, et al. Proteomics of CKD progression in the
chronic renal insufficiency cohort. Nat Commun. 2023; 14 (1): 6340. doi: 10.1038/s41467 …
chronic renal insufficiency cohort. Nat Commun. 2023; 14 (1): 6340. doi: 10.1038/s41467 …