The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

The number of DNA polymerases identified in each organism has mushroomed in the past
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and
prevent mutation. Here we use C. elegans whole genome sequencing to systematically …

Chemotherapy-resistant urothelial carcinoma has no uniformly curative therapy.
Understanding how selective pressure from chemotherapy directs the evolution of urothelial …

Oncogene activation creates DNA replication stress (RS) in cancer cells, which can
generate under-replicated DNA regions (UDRs) that persist until cells enter mitosis. UDRs …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Advanced and metastatic tumors with complex treatment histories drive cancer mortality.
Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and …

Translesion DNA synthesis (TLS) facilitates replication over damaged or difficult-to-replicate
templates by employing specialized DNA polymerases. We investigate the effect on …

Background Genomic mutations caused by cytotoxic agents used in cancer chemotherapy
may cause secondary malignancies as well as contribute to the evolution of treatment …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …