Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

SS Pinho, I Alves, J Gaifem… - Cellular & Molecular …, 2023 - nature.com
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

The mycobacterial cell envelope—a moving target

CL Dulberger, EJ Rubin, CC Boutte - Nature Reviews Microbiology, 2020 - nature.com
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

Cell wall hydrolases in bacteria: insight on the diversity of cell wall amidases, glycosidases and peptidases toward peptidoglycan

A Vermassen, S Leroy, R Talon, C Provot… - Frontiers in …, 2019 - frontiersin.org
The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least
constituted of peptidoglycan (PG) but also of (lipo) teichoic acids, various polysaccharides …

[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact

GS Shetye, SG Franzblau, S Cho - Translational Research, 2020 - Elsevier
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

[HTML][HTML] Extracellular vesicles: An emerging platform in gram-positive bacteria

S Bose, S Aggarwal, DV Singh, N Acharya - Microbial Cell, 2020 - ncbi.nlm.nih.gov
Extracellular vesicles (EV), also known as membrane vesicles, are produced as an end
product of secretion by both pathogenic and non-pathogenic bacteria. Several reports …

Cu homeostasis in bacteria: the ins and outs

A Andrei, Y Öztürk, B Khalfaoui-Hassani, J Rauch… - Membranes, 2020 - mdpi.com
Copper (Cu) is an essential trace element for all living organisms and used as cofactor in
key enzymes of important biological processes, such as aerobic respiration or superoxide …

DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

KA Abrahams, SM Batt, SS Gurcha, N Veerapen… - Nature …, 2023 - nature.com
Mycobacterium tuberculosis is one of the global leading causes of death due to a single
infectious agent. Pretomanid and delamanid are new antitubercular agents that have …

New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria

MJ Nasiri, M Haeili, M Ghazi, H Goudarzi… - Frontiers in …, 2017 - frontiersin.org
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Drug-resistant tuberculosis 2020: where we stand

A Iacobino, L Fattorini, F Giannoni - Applied Sciences, 2020 - mdpi.com
Featured Application This comprehensive overview of drug-resistant tuberculosis will be
useful for researchers to expand their knowledge beyond mechanisms other than …