Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality
rates among cancer-related deaths in the United States. Originating from intestinal epithelial …

Defective DNA mismatch repair (dMMR) is associated with many cancer types including
colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract, brain and skin cancers …

Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive
DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, and colorectal …

Purpose: To analytically and clinically validate microsatellite instability (MSI) detection using
cell-free DNA (cfDNA) sequencing. Experimental Design: Pan-cancer MSI detection using …

Motivation: Microsatellite instability (MSI) is an important indicator of larger genome
instability and has been linked to many genetic diseases, including Lynch syndrome. MSI …

In current clinical practice, microsatellite instability (MSI) and mismatch repair deficiency
detection is performed with MSI-PCR and immunohistochemistry. Recent research has …

Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for
the management of malignant and benign neoplasms. Detecting circulating DNA in cancer …

Microsatellite instability (MSI) has been identified in several tumors arising from either
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …

Background In the past decade, systematic and comprehensive analyses of cancer
genomes have identified cancer driver genes and revealed unprecedented insight into the …

Microsatellite instability (MSI) is a genomic alteration in which microsatellites, usually of one
to four nucleotide repeats, accumulate mutations corresponding to deletions/insertions of a …