Technical progress in materials science and bioprinting has for the past few decades
fostered considerable advances in medicine. More recently, the understanding of the …

Abstract Development of the asymmetric amniotic sac—with the embryonic disc and
amniotic ectoderm occupying opposite poles—is a vital milestone during human embryo …

Morphogens play an essential role in cell fate specification and patterning including in
laying out the mammalian body plan during gastrulation. In vivo studies have shed light on …

High-throughput imaging methods can be applied to relevant cell culture models, fostering
their use in research and translational applications. Improvements in microscopy …

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a
formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have …

Embryogenesis is a highly regulated developmental process requiring complex mechanical
and biochemical microenvironments to give rise to a fully developed and functional embryo …

During embryogenesis, signaling molecules initiate cell diversification, sometimes via
stochastic processes, other times via the formation of long range gradients of activity which …