CD163 and inflammation: biological, diagnostic, and therapeutic aspects

A Etzerodt, SK Moestrup - Antioxidants & redox signaling, 2013 - liebertpub.com
Abstract Significance: The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-
specific protein and the upregulated expression of this receptor is one of the major changes …

[HTML][HTML] The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology

A Plevriti, M Lamprou, E Mourkogianni, N Skoulas… - Cells, 2024 - mdpi.com
Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and
chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome …

Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection

TH Burdo, A Weiffenbach, SP Woods, S Letendre… - Aids, 2013 - journals.lww.com
Objective: Here we evaluated whether neurocognitive disorders in HIV-infected individuals
on effective antiretroviral therapy (ART) are associated with persistent monocyte activation …

Human adipose tissue macrophages are enhanced but changed to an anti‐inflammatory profile in obesity

K Fjeldborg, SB Pedersen, HJ Møller… - Journal of …, 2014 - Wiley Online Library
Objective. Adipose tissue (AT) macrophages are increased in obesity and associated with
low grade inflammation. We aimed to characterize the phenotype of AT macrophages in …

Soluble CD163: a biomarker linking macrophages and insulin resistance

T Parkner, LP Sørensen, AR Nielsen, CP Fischer… - Diabetologia, 2012 - Springer
Abstract Aims/hypothesis Soluble CD163 (sCD163) was recently identified as a strong risk
marker for developing type 2 diabetes. We hypothesised that sCD163 independently …

Luteolin targets the toll-like receptor signaling pathway in prevention of hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice

EY Kwon, MS Choi - Nutrients, 2018 - mdpi.com
This study was to investigate the protective role of luteolin on inflammation-mediated
metabolic diseases, focusing on the role of luteolin in the modulation of the Toll-like receptor …

O-GlcNAcylation in immunity and inflammation: An intricate system

Y Li, M Xie, L Men, J Du - International journal of …, 2019 - spandidos-publications.com
Chronic, low‑grade inflammation associated with obesity and diabetes result from the
infiltration of adipose and vascular tissue by immune cells and contributes to cardiovascular …

Abdominal obesity contributes to neurocognitive impairment in HIV-infected patients with increased inflammation and immune activation

FR Sattler, J He, S Letendre, C Wilson… - JAIDS Journal of …, 2015 - journals.lww.com
Objective: We tested our hypothesis that abdominal obesity when associated with increased
levels of systemic and central nervous system immunoinflammatory mediators contributes to …

Obesity-associated T-cell and macrophage activation improve partly after a lifestyle intervention

IJB Van der Zalm, ES Van Der Valk… - International journal of …, 2020 - nature.com
Background The relation between low-grade inflammation and metabolic dysfunction in
obesity is not fully explored. Objective To evaluate immune parameters in the obese state …

Hyperglycemia induces inflammatory response of human macrophages to CD163-mediated scavenging of hemoglobin-haptoglobin complexes

L Matuschik, V Riabov, C Schmuttermaier… - International journal of …, 2022 - mdpi.com
Hyperglycemia, a hallmark of diabetes, can induce inflammatory programming of
macrophages. The macrophage scavenger receptor CD163 internalizes and degrades …