Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …

The mechanisms whereby Eomes controls tissue accumulation of T cells and strengthens
inflammation remain ill-defined. Here, we show that Eomes deletion in antigen-specific …

Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined
entities that diverge in their basic pathogenic mechanisms and clinical evolution but they …

Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …

Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL)
subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent …