Recent advances in the transition-metal-free synthesis of quinazolines

R Tamatam, D Shin - Molecules, 2023 - mdpi.com
Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a
variety of natural products and synthetic chemicals with a broad spectrum of biological and …

CuCl/DABCO/4-HO-TEMPO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted Quinazolines and 4H-3,1-Benzoxazines

B Han, XL Yang, C Wang, YW Bai, TC Pan… - The Journal of …, 2012 - ACS Publications
The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis
of heterocycles. As demonstrated, 2-substituted quinazolines and 4 H-3, 1-benzoxazines …

A review on the synthesis and chemical transformation of quinazoline 3-oxides

MJ Mphahlele - Molecules, 2022 - mdpi.com
The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable
attention due to their reactivity as intermediates in the synthesis of quinazoline analogues …

Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives

Z Chen, J Chen, M Liu, J Ding, W Gao… - The Journal of …, 2013 - ACS Publications
The first example of a copper-catalyzed cascade reaction of (2-aminophenyl) methanols with
aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has …

Highly Efficient One‐Pot Synthesis of 2‐Substituted Quinazolines and 4H‐Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite

CU Maheswari, GS Kumar… - Advanced Synthesis …, 2010 - Wiley Online Library
This communication describes a catalyst‐free synthesis of 2‐substituted quinazolines and
4H‐benzo [d][1, 3] oxazines using commericially available sodium hypochlorite as oxidant …

Synthesis of 4-aryl-7, 7-dimethyl-1, 2, 3, 4, 5, 6, 7, 8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials

M Kidwai, S Saxena, MKR Khan, SS Thukral - European journal of …, 2005 - Elsevier
A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7, 7-dimethyl-1,
2, 3, 4, 5, 6, 7, 8-octahydroquinazoline-2-one/thione-5-one derivatives is described which …

An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H2SO4 in water

Z Hassani, MR Islami, M Kalantari - Bioorganic & Medicinal Chemistry …, 2006 - Elsevier
In this investigation, a practical green chemistry procedure for synthesis of
octahydroquinazolinone according to the Biginelli reaction using 5, 5-dimethyl-1, 3 …

Copper-catalyzed multicomponent domino reaction of 2-bromoaldehydes, benzylamines, and sodium azide for the assembly of quinazoline derivatives

C Xu, FC Jia, ZW Zhou, SJ Zheng, H Li… - The Journal of Organic …, 2016 - ACS Publications
An efficient three-component domino reaction of 2-bromoaldehydes, benzylamines, and
sodium azide has been developed for the synthesis of quinazoline derivatives. This domino …

[HTML][HTML] Transition metal-free synthesis of 2-aryl quinazolines via alcohol dehydrogenation

P Hima, M Vageesh, M Tomasini, A Poater, R Dey - Molecular Catalysis, 2023 - Elsevier
We report here a transition metal-free synthesis of quinazoline derivatives starting from 2-
aminobenzyl alcohols and aryl amides via an alcohol dehydrogenation strategy promoted …

Inverse‐Electron‐Demand [4+ 2]‐Cycloaddition of 1, 3, 5‐triazinanes: Facile Approaches to Tetrahydroquinazolines

Y Zheng, L Tu, N Li, R Huang, T Feng… - Advanced Synthesis …, 2019 - Wiley Online Library
An unprecedented inverse‐electron‐demand [4+ 2] cycloaddition reaction of in situ
generated aza‐o‐quinone methides with 1, 3, 5‐triazinanes has been developed under mild …