From the Outside-In: The Francisella tularensis Envelope and Virulence

HM Rowe, JF Huntley - Frontiers in cellular and infection microbiology, 2015 - frontiersin.org
Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …

Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis

Q Jia, MA Horwitz - Frontiers in cellular and infection microbiology, 2018 - frontiersin.org
Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In
the 1900s, several vaccines were developed against tularemia including the killed “Foshay” …

Development of a multivalent subunit vaccine against tularemia using tobacco mosaic virus (TMV) based delivery system

S Banik, AA Mansour, RV Suresh, S Wykoff-Clary… - PloS one, 2015 - journals.plos.org
Francisella tularensis is a facultative intracellular pathogen, and is the causative agent of a
fatal human disease known as tularemia. F. tularensis is classified as a Category A Biothreat …

Repression of inflammasome by Francisella tularensis during early stages of infection

RJ Dotson, SM Rabadi, EL Westcott, S Bradley… - Journal of Biological …, 2013 - ASBMB
Francisella tularensis is an important human pathogen responsible for causing tularemia. F.
tularensis has long been developed as a biological weapon and is now classified as a …

Identification of disulfide bond isomerase substrates reveals bacterial virulence factors

G Ren, MM Champion, JF Huntley - Molecular microbiology, 2014 - Wiley Online Library
Bacterial pathogens are exposed to toxic molecules inside the host and require efficient
systems to form and maintain correct disulfide bonds for protein stability and function. The …

An O‐antigen glycoconjugate vaccine produced using protein glycan coupling technology is protective in an inhalational rat model of tularemia

LE Marshall, M Nelson, CH Davies… - Journal of …, 2018 - Wiley Online Library
There is a requirement for an efficacious vaccine to protect people against infection from
Francisella tularensis, the etiological agent of tularemia. The lipopolysaccharide (LPS) of F …

An improved tobacco mosaic virus (TMV)-conjugated multiantigen subunit vaccine against respiratory tularemia

AA Mansour, S Banik, RV Suresh, H Kaur… - Frontiers in …, 2018 - frontiersin.org
Francisella tularensis, the causative agent of the fatal human disease known as tularemia is
classified as a Category A Select Agent by the Centers for Disease Control. No licensed …

Antioxidant defenses of Francisella tularensis modulate macrophage function and production of proinflammatory cytokines

SM Rabadi, BC Sanchez, M Varanat, Z Ma… - Journal of Biological …, 2016 - ASBMB
Francisella tularensis, the causative agent of a fatal human disease known as tularemia, has
been used in the bioweapon programs of several countries in the past, and now it is …

Comparative evaluation of protective immunity against Francisella tularensis induced by subunit or adenovirus-vectored vaccines

M Zhao, Y Zhai, X Zai, Y Mao, E Hu, Z Wei… - Frontiers in Cellular …, 2023 - frontiersin.org
Tularemia is a highly contagious disease caused by infection with Francisella tularensis (Ft),
a pathogenic intracellular gram-negative bacterium that infects a wide range of animals and …

Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strain

K Richard, BJ Mann, L Stocker, EM Barry… - Clinical and Vaccine …, 2014 - Am Soc Microbiol
Francisella tularensis is a Gram-negative immune-evasive coccobacillus that causes
tularemia in humans and animals. A safe and efficacious vaccine that is protective against …