Large changes in detected selection signatures after a selection limit in mice bred for voluntary wheel-running behavior
In various organisms, sequencing of selectively bred lines at apparent selection limits has
demonstrated that genetic variation can remain at many loci, implying that evolution at the …
demonstrated that genetic variation can remain at many loci, implying that evolution at the …
A meta-analysis of whole-body and heart mass effect sizes from a long-term artificial selection experiment for high voluntary exercise
NE Schwartz, T Garland - Journal of Experimental Biology, 2024 - journals.biologists.com
Selection experiments play an increasingly important role in comparative and evolutionary
physiology. However, selection experiments can be limited by relatively low statistical …
physiology. However, selection experiments can be limited by relatively low statistical …
[HTML][HTML] Effects of food restriction on voluntary wheel-running behavior and body mass in selectively bred High Runner lines of mice
Z Thompson, IAT Fonseca, W Acosta, L Idarraga… - Physiology & …, 2024 - Elsevier
Food restriction can have profound effects on various aspects of behavior, physiology, and
morphology. Such effects might be amplified in animals that are highly active, given that …
morphology. Such effects might be amplified in animals that are highly active, given that …
Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading
We and others have shown that application of high-level mechanical loading promotes the
formation of transient plasma membrane disruptions (PMD) which initiate …
formation of transient plasma membrane disruptions (PMD) which initiate …
[HTML][HTML] Maternal exercise opportunity before, during, and after pregnancy alters maternal care behavior and offspring development and survival, but has few effects …
NE Schwartz, MP Schmill, MD Cadney, AA Castro… - Physiology & …, 2025 - Elsevier
Early-life experiences, especially during critical periods of development and growth, can
have long-lasting effects on adult phenotypes. Parents are a crucial part of the offspring …
have long-lasting effects on adult phenotypes. Parents are a crucial part of the offspring …
Hippocampal long-term potentiation is modulated by exercise-induced alterations in dopaminergic synaptic transmission in mice selectively bred for high voluntary …
JMP Phan, J Yi, JHA Foote… - Restorative …, 2024 - journals.sagepub.com
Background High-Runner (HR) mice, selectively bred for increased voluntary wheel running
behavior, exhibit heightened motivation to run. Exercise has been shown to influence …
behavior, exhibit heightened motivation to run. Exercise has been shown to influence …