[HTML][HTML] Parallel multi-droplet platform for reaction kinetics and optimization

NS Eyke, TN Schneider, B Jin, T Hart, S Monfette… - Chemical …, 2023 - pubs.rsc.org
We present an automated droplet reactor platform possessing parallel reactor channels and
a scheduling algorithm that orchestrates all of the parallel hardware operations and ensures …

Self-driving laboratories for chemistry and materials science

G Tom, SP Schmid, SG Baird, Y Cao, K Darvish, H Hao… - 2024 - chemrxiv.org
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with the autonomization of …

Growing value of data standardization: Allotrope Foundation Connect Workshop Proceedings

H Kayser, ML Lau - Drug Discovery Today, 2024 - Elsevier
Highlights•Allotrope Data Model ensures data integrity through validation.•Allotrope
Framework's foundation is built upon the versatile HDF5.•Multiple tools enable easy access …

[HTML][HTML] Automated LC-MS analysis and data extraction for high-throughput chemistry

J Mason, H Wilders, DJ Fallon, RP Thomas, JT Bush… - Digital …, 2023 - pubs.rsc.org
High-throughput experimentation for chemistry and chemical biology has emerged as a
highly impactful technology, particularly when applied to Direct-to-Biology. Analysis of the …

Improved assay development of pharmaceutical modalities using feedback-controlled liquid chromatography optimization

FN Aldine, AN Singh, H Wang, DM Makey… - … of Chromatography A, 2024 - Elsevier
Abstract Development of meaningful and reliable analytical assays in the (bio)
pharmaceutical industry can often be challenging, involving tedious trial and error …

[HTML][HTML] A comparative study of transient flow rate steps and ramps for the efficient collection of kinetic data

L Schrecker, J Dickhaut, C Holtze, P Staehle… - Reaction Chemistry & …, 2024 - pubs.rsc.org
Transient cumulative flow rate varying methods have proven very effective for the collection
of residence time series data for reactions in continuous flow. In this study, comparisons will …

[HTML][HTML] Calibration-free reaction yield quantification by HPLC with a machine-learning model of extinction coefficients

MA McDonald, BA Koscher, RB Canty, KF Jensen - Chemical Science, 2024 - pubs.rsc.org
Reaction optimization and characterization depend on reliable measures of reaction yield,
often measured by high-performance liquid chromatography (HPLC). Peak areas in HPLC …

[HTML][HTML] Improving protein therapeutic development through cloud-based data integration

GA Van Den Driessche, D Bailey, EO Anderson… - SLAS technology, 2023 - Elsevier
Pharma 4.0 is a digital evolution of the pharmaceutical industry that automates scientists'
traditional workflows with the implementation of modern technologies like cloud pipelines …

Ab Initio Design of Ni‐Rich Cathode Material with Assistance of Machine Learning for High Energy Lithium‐Ion Batteries

X Zhang, D Mu, S Lu, Y Zhang, Y Zhang… - Energy & … - Wiley Online Library
With the widespread use of lithium‐ion batteries in electric vehicles, energy storage, and
mobile terminals, there is an urgent need to develop cathode materials with specific …

[HTML][HTML] Open Data Sesame! Key Takeaways from Chemistry Europe's First Data Day

A Straube, FR Novara - Chemistry International, 2023 - degruyter.com
Ensuring research data are made openly available and are useful to everyone is an
increasingly important area of focus for science publishers. Chemistry Europe has invited …