Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Personalized treatment is defined as choosing the “right treatment for the right person at the
right time.” Although psychiatry has not yet reached this level of precision, we are on the way …

Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Objectives Evidence suggests accelerated aging mechanisms in bipolar disorder (BD),
including DNA methylation (DNAm) aging in blood. However, it is unknown whether such …

Objective: Bipolar disorders increase the risk of dementia and show biological and brain
alterations, which resemble accelerated aging. Lithium may counter some of these …

Depression is a common neurological disease that seriously affects human health. There
are many hypotheses about the pathogenesis of depression, and the most widely …

There is high mortality among patients with bipolar disorder (BD). Studies have reported
accelerated biological aging in patients with BD. Recently, Horvath and Hannum et al …

Telomere length is a promising biomarker for age-related disease and a potential anti-
ageing drug target. Here, we study the genetic architecture of telomere length and the …

The purpose of the present meta-analysis was to compare leukocyte telomere length (LTL),
a proposed marker for cell aging, between patients with bipolar disorder (BD) and healthy …