Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

BCLA CLEAR-Anatomy and physiology of the anterior eye

LE Downie, S Bandlitz, JPG Bergmanson… - Contact Lens and …, 2021 - Elsevier
A key element of contact lens practice involves clinical evaluation of anterior eye health,
including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal …

Microvascular thrombosis: experimental and clinical implications

MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …

Corneal nerves and their role in dry eye pathophysiology

A Vereertbrugghen, JG Galletti - Experimental Eye Research, 2022 - Elsevier
As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

[HTML][HTML] Corneal epithelial “Neuromas”: a case of mistaken identity?

MA Stepp, S Pal-Ghosh, LE Downie, AC Zhang… - Cornea, 2020 - journals.lww.com
Laser scanning in vivo confocal microscopy is a useful clinical tool to assess the corneal
nerves in human and laboratory animals. With this new technology, the use of terms such as …

[HTML][HTML] Serial block-face scanning electron microscopy (SBF-SEM) of biological tissue samples

JA Courson, PT Landry, T Do… - Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Serial block-face scanning electron microscopy (SBF-SEM) allows for the collection of
hundreds to thousands of serially-registered ultrastructural images, offering an …

[HTML][HTML] Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice

Y Wu, E Li, M Knight, G Adeniyi-Ipadeola… - PLoS neglected …, 2021 - journals.plos.org
Ascariasis is one of the most common infections in the world and associated with significant
global morbidity. Ascaris larval migration through the host's lungs is essential for larval …

[HTML][HTML] Neuronal-epithelial cell alignment: A determinant of health and disease status of the cornea

H Tuck, M Park, M Carnell, J Machet, A Richardson… - The Ocular Surface, 2021 - Elsevier
Purpose How sensory neurons and epithelial cells interact with one another, and whether
this association can be considered an indicator of health or disease is yet to be elucidated …

[HTML][HTML] Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy …

P Parlanti, S Pal-Ghosh, A Williams, G Tadvalkar… - Experimental eye …, 2020 - Elsevier
The intraepithelial corneal nerves (ICNs) that innervate the corneal epithelium are
maintained through interactions with corneal epithelial cells and the extracellular matrix they …

[HTML][HTML] Impact of Obesity and Age on Mouse Corneal Innervation at the Epithelial-Stromal Interface

JA Courson, RE Rumbaut… - … Ophthalmology & Visual …, 2024 - iovs.arvojournals.org
Purpose: The corneal epithelium is the most highly innervated structure in the body.
Previously, we reported a novel event whereby stromal axons fuse with basal epithelial …