Mitochondria as signaling organelles control mammalian stem cell fate
RP Chakrabarty, NS Chandel - Cell stem cell, 2021 - cell.com
Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate,
which is driven and maintained largely by tissue-resident somatic stem cell populations …
which is driven and maintained largely by tissue-resident somatic stem cell populations …
Distinct bone marrow blood vessels differentially regulate haematopoiesis
Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …
Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …
Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment
A Ludin, S Gur-Cohen, K Golan… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …
Role of bioactive sphingolipids in physiology and pathology
A Gomez-Larrauri, N Presa… - Essays in …, 2020 - portlandpress.com
Sphingolipids are a class of complex lipids containing a backbone of sphingoid bases,
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …
namely the organic aliphatic amino alcohol sphingosine (Sph), that are essential …
[HTML][HTML] G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent
LJ Bendall, KF Bradstock - Cytokine & growth factor reviews, 2014 - Elsevier
G-CSF was among the first cytokines to be identified and rapidly transitioned into clinical
medicine. Initially used to promote the production of neutrophils in patients with …
medicine. Initially used to promote the production of neutrophils in patients with …
[HTML][HTML] Daily onset of light and darkness differentially controls hematopoietic stem cell differentiation and maintenance
Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone
marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic …
marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic …
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow
A Ludin, T Itkin, S Gur-Cohen, A Mildner, E Shezen… - Nature …, 2012 - nature.com
Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow
stromal cell types. Here we identified rare activated bone marrow monocytes and …
stromal cell types. Here we identified rare activated bone marrow monocytes and …
Finding a way out: S1P signaling and immune cell migration
AAL Baeyens, SR Schwab - Annual review of immunology, 2020 - annualreviews.org
The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …