The prevalence of obesity has tripled over the past five decades. Obesity, especially visceral
obesity, is closely related to hypertension, increasing the risk of primary (essential) …

The transient receptor potential (TRP) channel superfamily is a group of non-selective cation
channels functioning as cellular sensors for a wide range of physical, chemical and …

Chronic inflammation of white adipose tissue is a key link between obesity and the
associated metabolic syndrome. Transient receptor potential melastatin-like 7 (TRPM7) is …

Diabetes and obesity have emerged as major global health concerns. Glucagon-like peptide-
1 (GLP-1), a natural incretin hormone, stimulates insulin production and suppresses …

Sleep‐disordered breathing (SDB) affects over 50% of obese individuals. Exaggerated
hypoxic chemoreflex is a cardinal trait of SDB in obesity. We have shown that leptin acts in …

Background Obesity can cause hypertension and exacerbates sleep-disordered breathing
(SDB). Leptin is an adipocyte-produced hormone, which increases metabolic rate …

It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique,
being inhibited by relatively small falls in PaO2 well above those known to inhibit electron …

Agouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily
expressed in hypothalamic neurons. Nevertheless, the expression and functional …

The maintenance of glucose homeostasis is obligatory for health and survival. It relies on
peripheral glucose sensing and signalling between the brain and peripheral organs via …

The phenotypic transformation of vascular smooth muscle cells (VSMCs) plays a key role in
the pathological process of atherosclerosis (AS), and TRPM7 is involved in this process. In …