Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant
patient and population burdens. In addition to the cutaneous signs and symptoms, growing …

Background Autism spectrum disorders (ASD) are complex conditions whose pathogenesis
may be attributed to gene–environment interactions. There are no definitive mechanisms …

Importance The prevalence of autism spectrum disorder (ASD) in US children has increased
during the past decades. Immunologic dysfunction has recently emerged as a factor …

Atopic dermatitis (AD) is a chronic inflammatory skin disease presenting with recurrent
eczematous lesions and intense pruritus. It is common and affects both children and adults …

BackgroundComorbid physical conditions may be more common in people with autism
spectrum disorder (ASD) than other people. AimsTo identify what is and what is not known …

Mast cells (MC) are ubiquitous in the body, and they are critical for not only in allergic
diseases but also in immunity and inflammation, including having potential involvement in …

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder without a
known cure. Current standard-of-care treatments focus on addressing core symptoms …

Psychiatric disorders are highly heritable and associated with a wide variety of social
adversity and physical health problems. Using genetic liability (rather than phenotypic …

Numerous studies have reported immune system disturbances in individuals with autism
and their family members; however, there is considerable variability in findings with respect …