This report explores the available curative molecules directed against hepatocellular
carcinoma (HCC). Limited efficiency as well as other drawbacks of existing molecules led to …

Loss of mitosis regulation is a common feature of malignant cells that leads to aberrant cell
division with inaccurate chromosome segregation. The mitotic checkpoint is responsible for …

Different groups have reported the Crocin anticancer activity. We previously showed Crocin-
induced apoptosis in rat model of breast and gastric cancers, through the increased Bax/Bcl …

Tubulin, an important target in tumor therapy, is one of the hotspots in the field of
antineoplastic drugs in recent years, and it is of great significance to design and screen new …

Saffron (Crocus sativus L.) byproducts are considered as a cheap source of bioactive
polyphenolics endowed with potential antioxidant effects. The saffron biowaste is utilized for …

Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent skin malignancy, and the
effective therapy still remains a challenge. Crocin can be used for cSCC therapy. This study …

Crocetin and crocin are two important carotenoids isolated from saffron (Crocus sativus L.),
which have been used as natural biomedicines with beneficial effects for improving the …

Abstract Methyl-β-cyclodextrin (MCD), an established pharmacological excipient,
depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD …

Human body temperature limits below 40° C during heat stroke or fever. The implications of
prolonged exposure to the physiologically relevant temperature (40° C) on cellular …

Background Cervical cancer is a prevalent tumor mainly induced by Human Papilloma Virus
(HPV). Autophagy was inactivated with HPV to promote cancer progression. Here we …