Drug-drug interactions and synergy: from pharmacological models to clinical application
L Calzetta, C Page, MG Matera, M Cazzola… - Pharmacological …, 2024 - Elsevier
This review explores the concept of synergy in pharmacology, emphasizing its importance in
optimizing treatment outcomes through the combination of drugs with different mechanisms …
optimizing treatment outcomes through the combination of drugs with different mechanisms …
[HTML][HTML] Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral …
M Kim, H Kim, BG Kang, J Lee, T Kim, H Lee, J Jung… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Exploiting synthetic lethality (SL) relationships between protein pairs has
emerged as an important avenue for the development of anti-cancer drugs. Nicotinamide …
emerged as an important avenue for the development of anti-cancer drugs. Nicotinamide …
Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells
Z Wang, Y Li, W Zhao, S Jiang, Y Huang… - … and Targeted Therapy, 2023 - nature.com
Prostate cancer (PCa) is the second most prevalent malignancy in males across the world. A
greater knowledge of the relationship between protein abundance and drug responses …
greater knowledge of the relationship between protein abundance and drug responses …
A Comprehensive In Vitro Characterization of a New Class of Indole-Based Compounds Developed as Selective Haspin Inhibitors
V Vestuto, T Ciaglia, S Musella… - Journal of Medicinal …, 2024 - ACS Publications
Haspin is an emerging, but rather unexplored, divergent kinase involved in tumor growth by
regulating the mitotic phase. In this paper, the in-silico design, synthesis, and biological …
regulating the mitotic phase. In this paper, the in-silico design, synthesis, and biological …
Identification of a novel protein phosphatase 2A activator, PPA24, as a potential therapeutic for FOLFOX-resistant colorectal cancer
A series of compounds were designed utilizing molecular modeling and fragment-based
design based upon the known protein phosphatase 2A (PP2A) activators, NSC49L and …
design based upon the known protein phosphatase 2A (PP2A) activators, NSC49L and …
[HTML][HTML] Combined effects of two phytoalexins, brassinin and camalexin, on the cells of colorectal origin
A Sierosławska, A Rymuszka - Toxicon, 2023 - Elsevier
Brassinin and camalexin belong to phytoalexins, plant compounds generated in the
response to stress. Both compounds are known to be cytotoxic to several cancer cell lines …
response to stress. Both compounds are known to be cytotoxic to several cancer cell lines …
Mind the Curve: Dose–Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies
O Fuentealba-Manosalva, M Mansilla… - International Journal of …, 2023 - mdpi.com
Drug combinations are increasingly studied in the field of anticancer agents. Mathematical
models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while …
models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while …
A novel combinatorial approach using sulforaphane-and withaferin A-rich extracts for prevention of estrogen receptor-negative breast cancer through epigenetic and …
MM Rahman, H Wu, TO Tollefsbol - Scientific Reports, 2024 - nature.com
Abstract Estrogen receptor-negative [ER (−)] mammary cancer is the most aggressive type of
breast cancer (BC) with higher rate of metastasis and recurrence. In recent years, dietary …
breast cancer (BC) with higher rate of metastasis and recurrence. In recent years, dietary …
[HTML][HTML] Targeting the multidrug and toxin extrusion 1 gene (SLC47A1) sensitizes glioma stem cells to temozolomide
DC Batara, SW Park, HJ Kim, SY Choi… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, with an extremely
poor prognosis due to resistance to standard-of-care treatments. Strong evidence suggests …
poor prognosis due to resistance to standard-of-care treatments. Strong evidence suggests …
Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells
MM Rahman, TO Tollefsbol - Cancer Cell International, 2024 - Springer
Background Epigenetic phytochemicals are considered as an efficacious and safe
alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions …
alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions …