Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

Mutations in genes encoding the intermediate filament nuclear lamins and associated
proteins cause a wide spectrum of diseases sometimes called “laminopathies.” Diseases …

Mutations in the lamin A/C gene (LMNA) cause a variety of human diseases including Emery-
Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria …

The nuclear lamina is a key structural element of the metazoan nucleus. However, the
structural organization of the major proteins composing the lamina is poorly defined. Using …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

The nuclear lamina is an intermediate filament meshwork adjacent to the inner nuclear
membrane (INM) that plays a critical role in maintaining nuclear shape and regulating gene …

Nuclear lamins comprise the nuclear lamina, a scaffold-like structure that lines the inner
nuclear membrane. B-type lamins are present in almost all cell types, but A-type lamins are …

Laminopathies comprise a group of inherited diseases with variable clinical phenotypes,
caused by mutations in the lamin A/C gene (LMNA). A prominent feature in several of these …

Lamins, the major components of the nuclear lamina, have gained rapidly increasing
interest over the past decade as lamin mutations were found to cause numerous devastating …