On the feasibility of time-resolved X-ray powder diffraction of macromolecules using laser-driven ultrafast X-ray sources
KP Khakurel, G Žoldák, B Angelov… - Applied …, 2024 - journals.iucr.org
With the emergence of ultrafast X-ray sources, interest in following fast processes in small
molecules and macromolecules has increased. Most of the current research into ultrafast …
molecules and macromolecules has increased. Most of the current research into ultrafast …
New perspectives in macromolecular powder diffraction using single-photon-counting strip detectors: high-resolution structure of the pharmaceutical peptide …
M Spiliopoulou, F Karavassili… - … A: Foundations and …, 2021 - journals.iucr.org
Advances in instrumentation, as well as the development of powerful crystallographic
software have significantly facilitated the collection of high-resolution diffraction data and …
software have significantly facilitated the collection of high-resolution diffraction data and …
Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction
DP Triandafillidis, N Parthenios… - … Section D: Structural …, 2020 - journals.iucr.org
This study focuses on the polymorphism of human insulin (HI) upon the binding of the
phenolic derivatives p-coumaric acid or trans-resveratrol over a wide pH range. The …
phenolic derivatives p-coumaric acid or trans-resveratrol over a wide pH range. The …
High-throughput macromolecular polymorph screening via an NMR and X-ray powder diffraction synergistic approach: the case of human insulin co-crystallized with …
M Spiliopoulou, A Valmas… - Journal of Applied …, 2021 - journals.iucr.org
Regular injections of insulin provide life-saving benefits to millions of diabetics. Apart from
native insulin and insulin analogue formulations, microcrystalline insulin suspensions are …
native insulin and insulin analogue formulations, microcrystalline insulin suspensions are …
Exploring the complex map of insulin polymorphism: a novel crystalline form in the presence of m-cresol
F Karavassili, A Valmas, M Dimarogona… - … Section D: Structural …, 2020 - journals.iucr.org
In this study, the first crystal structure of a novel crystal form of human insulin bound to meta-
cresol in an acidic environment is reported. The combination of single-crystal and powder X …
cresol in an acidic environment is reported. The combination of single-crystal and powder X …