The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Spatial proteomics is an interdisciplinary field that investigates the localization and dynamics
of proteins, and it has gained extensive attention in recent years, especially the subcellular …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

The structures and functions of organelles in cells depend on each other but have not been
systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and …

Lipid exchange between the endoplasmic reticulum (ER) and peroxisomes is necessary for
the synthesis and catabolism of lipids, the trafficking of cholesterol, and peroxisome …

Peroxisomes account for~ 35% of total H2O2 generation in mammalian tissues. Peroxisomal
ACOX 1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation …

Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We
report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb …

Abstract Peroxiredoxin 5 (PRDX5) was the last member to be identified among the six
mammalian peroxiredoxins. It is also the unique atypical 2-Cys peroxiredoxin in mammals …

Cellular functions are dictated by protein content and activity. There are numerous strategies
to regulate proteins varying from modulating gene expression to post‐translational …

Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which
transfers ubiquitin to~ 35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it …