The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting
as part of biological defense system leading to the formation of a fibrin clot in which activated …

Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …

Study design Cross-sectional cohort analysis of patients with Modic Changes (MC).
Objective Our goal was to characterize the molecular and cellular features of MC bone …

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …

Abstract Background Context Modic changes (MCs) are magnetic resonance imaging (MRI)
evidence of inflammatory and fibrotic vertebral bone marrow lesions that associate with …

Background Acute trauma on intervertebral discs (IVDs) is thought to be one of the risk
factors for IVD degeneration. The pathophysiology of IVD degeneration induced by single …

Degenerative disc disease is a progressive, chronic disorder with strong association to pain,
where the dysregulated tissue environment signals disc cells, thereby leading to a low …

Objective Modic changes (MC) are vertebral bone marrow lesions seen on magnetic
resonance images, that associate with disc degeneration and low back pain (LBP). Few …

The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage, and plays an important
role in the diffusion of nutrients into the intervertebral discs. Its damage may seriously affect …

Background Motivation and necessity to adopt minimally invasive therapies in the field of
spinal regenerative medicine is increasing. Autologous platelet-rich plasma (PRP) therapy …