Highlights•Metabolic cybergenetics promises unprecedented real-time control of
fermentations.•Optogenetic regulators make ideal actuators for metabolic cybergenetics.• …

Signal transduction networks generate characteristic dynamic activities to process
extracellular signals and guide cell fate decisions such as to divide or differentiate. The …

Although the quantity and quality of single‐cell data have progressed rapidly, making
quantitative predictions with single‐cell stochastic models remains challenging. The …

Recent single-cell studies have revealed that yeast stress response involves transcription
factors that are activated in pulses. However, it remains unclear whether and how these …

Synthesis of gene products in bursts of multiple molecular copies is an important source of
gene expression variability. This paper studies large deviations in a Markovian drift-jump …

We present a general theory of noisy genetic oscillators with externally regulated production
rate and multiplicative noise. The observables that characterize the genetic oscillator are …

Stochastic pulsatile dynamics have been observed in an increasing number of biological
circuits with known mechanism involving feedback control and bistability. Surprisingly …

Eukaryotic cells activate the S-phase checkpoint signal transduction pathway in response to
DNA replication stress. Affected by the noise in biochemical reactions, such activation …

Cells often encounter various external and internal signals in a non-sustained pulsatile
manner with varying amplitude, duration and residual value. However, the effect of signal …

Abstract Analysis and modelling of dose-survival curves of cells and tissues are often used
to assess therapeutic efficacy or environmental risks, much less to infer the intracellular …