Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …

Drug discovery is a highly complex and costly process, which demands integrated efforts in
several relevant aspects involving innovation, knowledge, information, technologies …

An automated approach for the rapid analysis of protein structure has been developed and
used to study acid-induced conformational changes in human growth hormone. The labeling …

We report the solution structure of human prolactin determined by NMR spectroscopy. Our
result is a significant improvement over a previous structure in terms of number and …

Human prolactin is a 199-residue (23kDa) protein closely related to growth hormone and
placental lactogen with properties and functions resembling both a hormone and a cytokine …

Backbone amide hydrogen exchange rates can be used to describe the dynamic properties
of a protein. Amide hydrogen exchange rates in a native protein may vary from milliseconds …

Protein therapeutics are rapidly transforming the pharmaceutical industry. Unlike for small
molecule therapeutics, current technologies are challenged to provide the rapid, high …

A61K47/50—Medicinal preparations characterised by the non-active ingredients used, eg
carriers or inert additives; Targeting or modifying agents chemically bound to the active …

Human growth hormone (hGH) is synthesized by somatotroph cells of the anterior pituitary
gland and induces cell proliferation and growth. This protein has been approved for the …

Weak and transient protein–protein interactions underlie numerous biological processes.
However, the location of the interaction sites of the specific complexes and the effect of …