Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Self-maintaining resident macrophages populate all mammalian organs. In addition to their
role as immune sentinels, macrophages perform day-to-day functions essential to tissue …

Cancer cell dissemination during very early stages of breast cancer proceeds through poorly
understood mechanisms. Here we show, in a mouse model of HER2+ breast cancer, that a …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Specialized phagocytes are found in the most primitive multicellular organisms. Their roles
in homeostasis and in distinguishing self from non-self have evolved with the complexity of …

Macrophages are diverse immune cells that reside in all tissues. Although macrophages
have been implicated in mammary-gland function, their diversity has not been fully …

Animal models are powerful tools to analyze the mechanism of the induction of human
breast cancer. Here we report a detailed analysis of mammary tumor progression in one …