GLP-1 receptor agonist as a modulator of innate immunity

J Chen, A Mei, Y Wei, C Li, H Qian, X Min… - Frontiers in …, 2022 - frontiersin.org
Glucagon-like peptide-1 (GLP-1) is a 30-amino acid hormone secreted by L cells in the
distal ileum, colon, and pancreatic α cells, which participates in blood sugar regulation by …

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

B Yeganeh, E Wiechec, SR Ande, P Sharma… - Pharmacology & …, 2014 - Elsevier
The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an
essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3 …

EGCG promotes PRKCA expression to alleviate LPS-induced acute lung injury and inflammatory response

M Wang, H Zhong, X Zhang, X Huang, J Wang, Z Li… - Scientific reports, 2021 - nature.com
Acute lung injury (ALI), which could be induced by multiple factors such as
lipopolysaccharide (LPS), refer to clinical symptoms of acute respiratory failure, commonly …

Emodin suppresses LPS-induced inflammation in RAW264. 7 cells through a PPARγ-dependent pathway

T Zhu, W Zhang, S Feng, H Yu - International immunopharmacology, 2016 - Elsevier
Inflammation is a defense and protective response to multiple harmful stimuli. Over and
uncontrolled inflammation can lead to local tissues or even systemic damages and injuries …

Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ‐Dependent NF‐κB Signaling Pathway In Vivo and In Vitro

T Zhu, Z Chen, G Chen, D Wang, S Tang… - Mediators of …, 2019 - Wiley Online Library
Asthma is characterized by airway inflammation and mucus hypersecretion. Curcumin
possessed a potent anti‐inflammatory property involved in the PPARγ‐dependent NF‐κB …

Glucagon like peptide-1 (GLP-1) modulates OVA-induced airway inflammation and mucus secretion involving a protein kinase A (PKA)-dependent nuclear factor-κB …

T Zhu, X Wu, W Zhang, M Xiao - International Journal of Molecular …, 2015 - mdpi.com
Asthma is a common chronic pulmonary inflammatory disease, featured with mucus hyper-
secretion in the airway. Recent studies found that glucagon like peptide-1 (GLP-1) analogs …

Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice

M Xiao, T Zhu, W Zhang, T Wang, YC Shen… - International journal of …, 2014 - mdpi.com
Acute lung injury (ALI) and its severe manifestation of acute respiratory distress syndrome
(ARDS) are well-known illnesses. Uncontrolled and self-amplified pulmonary inflammation …

Novel therapies to inhibit mucus synthesis and secretion in airway hypersecretory diseases

EVS Ha, DF Rogers - Pharmacology, 2016 - karger.com
Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus
hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially …

Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response

Q Qiu, W Zhang, K Liu, F Huang, J Su, L Deng… - European Journal of …, 2023 - Elsevier
Asthma is a persistent respiratory ailment that displays periodicity and is linked to the
equilibrium of T cells. Several compounds obtained from Chinese herbal medicines display …

Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway

W Huang, ML Li, MY Xia… - … Journal of Molecular …, 2018 - spandidos-publications.com
Asthma is a common chronic airway inflammation disease and is considered as a major
public health problem. Fisetin (3, 3', 4', 7-tetrahydroxyflavone) is a naturally occurring …