Disorder and function: a review of the dehydrin protein family
SP Graether, KF Boddington - Frontiers in plant science, 2014 - frontiersin.org
Dehydration proteins (dehydrins) are group 2 members of the late embryogenesis abundant
(LEA) protein family. The protein architecture of dehydrins can be described by the presence …
(LEA) protein family. The protein architecture of dehydrins can be described by the presence …
Intrinsically disordered proteins from A to Z
VN Uversky - The international journal of biochemistry & cell biology, 2011 - Elsevier
The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an
integrative biophysical approach that includes nuclear magnetic resonance spectroscopy …
integrative biophysical approach that includes nuclear magnetic resonance spectroscopy …
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
The all-atom additive CHARMM36 protein force field is widely used in molecular modeling
and simulations. We present its refinement, CHARMM36m (http://mackerell. umaryland …
and simulations. We present its refinement, CHARMM36m (http://mackerell. umaryland …
ALS mutations disrupt phase separation mediated by α-helical structure in the TDP-43 low-complexity C-terminal domain
RNA-binding protein TDP-43 mediates essential RNA processing but forms cytoplasmic
neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It …
neuronal inclusions via its C-terminal domain (CTD) in amyotrophic lateral sclerosis (ALS). It …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a
LM Bessa, S Guseva, AR Camacho-Zarco, N Salvi… - Science …, 2022 - science.org
The processes of genome replication and transcription of SARS-CoV-2 represent important
targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of …
targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of …
Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation
Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
Epigallocatechin gallate (EGCG) from green tea can induce apoptosis in cancerous cells,
but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR …
but the underlying molecular mechanisms remain poorly understood. Using SPR and NMR …
A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding
M Botova, AR Camacho-Zarco, J Tognetti… - Science …, 2024 - science.org
The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …
the viral genome and is essential for viral function. The central disordered domain comprises …