Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the
structure of macromolecular complexes. The biological function of macromolecular …

Genome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been …

Advances in microscopy instruments and image processing algorithms have led to an
increasing number of cryo-electron microscopy (cryo-EM) maps. However, building accurate …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

Structural modeling of macromolecular complexes greatly benefits from interactive
visualization capabilities. Here we present the integration of several modeling tools into …

A set of software tools for building and distributing models of macromolecular assemblies
uses an integrative structure modeling approach, which casts the building of models as a …

Genome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been …

The 26S proteasome is at the executive end of the ubiquitin-proteasome pathway for the
controlled degradation of intracellular proteins. While the structure of its 20S core particle …

Eukaryotic translation initiation requires the recruitment of the large, multiprotein eIF3
complex to the 40S ribosomal subunit. We present X-ray structures of all major components …