Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic
loosening after artificial joint replacement, among which the imbalance of osteogenesis and …

Obesity is a weight-related disorder characterized by excessive adipose tissue growth and
dysfunction which leads to the onset of a systemic chronic low-grade inflammatory state …

Osteoblastic bone metastases are commonly detected in patients with advanced prostate
cancer (PCa) and are associated with an increased mortality rate. Dickkopf-1 (DKK-1) …

Abstract Sulfiredoxin 1 (SRXN1) is a pivotal regulator of the antioxidant response in
eukaryotic cells. However, the role of SRXN1 in hepatocellular carcinoma (HCC) is far from …

Background The interaction between programmed death receptor (PD-1) and its ligand (PD-
L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms …

Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway
that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB …

Abstract Ethnopharmacological relevance Litchi chinensis Sonn.(Litchi) seed, a traditional
Chinese medicine, is habitually used in the clinical treatment of prostate cancer (PCa) …

Osteosarcoma (OS) remains one of the most threatening primary malignant human tumors of
the bone, especially in the first or second decade of life. Unfortunately, the clinical …

Simple Summary Keratin-7 overexpression has been associated with poor prognosis in
several cancers. To determine its prognostic relevance in prostate cancer, cohorts of …

Protein kinases C (PKCs) are a family of serine/threonine kinases involved in various
cellular processes, including proliferation, differentiation, cell survival, and apoptosis. Here …