Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Human primary monocytes comprise a heterogeneous population that can be classified into
three subsets based on CD14 and CD16 expression: classical (CD14high/CD16−) …

Atherosclerosis is one of the main complications of diabetes involving multiple causative
factors. Dysfunction of the vascular endothelium is a hallmark of most conditions that are …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

There are many age-associated changes in the respiratory and pulmonary immune system.
These changes include decreases in the volume of the thoracic cavity, reduced lung …

Mitochondrial components, including mitochondrial DNA (mtDNA), when released
extracellularly, can act as “damage‐associated molecular pattern”(DAMP) agents and cause …