Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
[HTML][HTML] The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance
W Dermauw, T Van Leeuwen - Insect biochemistry and molecular biology, 2014 - Elsevier
About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics.
The white gene turned out to encode the first well studied ABC transporter in arthropods …
The white gene turned out to encode the first well studied ABC transporter in arthropods …
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
JH Maltbaek, S Cambier, JM Snyder, DB Stetson - Immunity, 2022 - cell.com
The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that …
ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development
Y Hee Choi, AM Yu - Current pharmaceutical design, 2014 - ingentaconnect.com
Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …
Targeting multidrug resistance in cancer
G Szakács, JK Paterson, JA Ludwig… - Nature reviews Drug …, 2006 - nature.com
Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …
most cases, multiple drugs are used, as resistance to single agents occurs almost …
Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders
E Gil-Martins, DJ Barbosa, V Silva, F Remião… - Pharmacology & …, 2020 - Elsevier
ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …
superfamily of proteins in living species, playing an important role in many biological …
Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
[HTML][HTML] Renal drug transporters and their significance in drug–drug interactions
J Yin, J Wang - Acta Pharmaceutica Sinica B, 2016 - Elsevier
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …
The role of ABC transporters in drug resistance, metabolism and toxicity
H Glavinas, P Krajcsi, J Cserepes… - Current drug …, 2004 - ingentaconnect.com
ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …
characterized by homologous ATP-binding, and large, multispanning transmembrane …