Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …

Enhancer elements are genomic regulatory sequences that direct the selective expression
of genes so that genetically identical cells can differentiate and acquire the highly …

Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …

The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …

Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …

Activity of estrogen, a sex steroid hormone, is not only limited to the reproductive organs but
also involves other organs and tissues, including skeletal muscle. In postmenopausal …