Disulfiram (DSF) has been used as an alcoholism drug for 70 years. Recently, it has
attracted increasing attention owing to the distinguished anticancer activity, which can be …

Although copper–ligand complexes appear to be promising as a new class of therapeutics,
other than the family of copper (II) coordination compounds referred to as casiopeínas these …

Platinum-based chemotherapy is widely used to treat various cancers. However, exogenous
platinum is likely to cause severe side effects and drug resistance induced by upregulated …

Disulfiram (DSF) is an FDA-approved drug that has been repurposed for cancer treatment. It
showed excellent anticancer efficacy in combination with copper ions (Cu). Several active …

Platinum-based anticancer drugs currently available in the market are associated with
severe side effects. Therefore, extensive research has been performed to design and …

Metal complexes are of increasing interest as pharmaceutical agents in cancer diagnostics
and therapeutics, while some of them suffer from issues such as limited water solubility and …

Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …

Micheal addition reaction of the microcrystalline cellulose (MCC)(1) with acrylonitrile (2)
afford the corresponding microcrystalline cyanoethyl cellulose (MCEC) which cyclized via …

Background Pancreatic cancer stem cells (CSCs) are responsible for resistance to standard
therapy, metastatic potential, and disease relapse following treatments. The current therapy …

Disulfiram (DSF) is an FDA approved anti-alcoholism drug in use for more than 60 years.
Recently, antitumor activity of the DSF/copper (DSF/Cu) complex has been identified. Its anti …