Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite
widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths …

Immunological memory is a remarkable phenomenon in which survival of an initial infection
by a pathogen leads to life-long protection from disease upon subsequent exposure to that …

Objective: The burden of cancer among persons living with HIV/AIDS (PLWHA) is substantial
and increasing. We assessed the prevalence of modifiable cancer risk factors among adult …

Human immunodeficiency virus (HIV) disease is associated with dysregulation and
dysfunction involving all major lymphocyte populations, including B cells. Such perturbations …

We assessed a cohort of people living with human immunodeficiency virus (PLWH)(n= 110)
and HIV negative controls (n= 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all …

A variety of B-cell dysfunctions are manifested during HIV-1 infection, as reported early
during the HIV-1 epidemic. It is not unusual that the pathogenic mechanisms presented to …

Memory B cells (MBCs) are key providers of long-lived immunity against infectious disease,
yet in chronic viral infection, they do not produce effective protection. How chronic viral …

Life-threatening invasive fungal infections are becoming increasingly common, at least in
part due to the prevalence of medical interventions resulting in immunosuppression …

T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to
antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and …

Long-term changes in the immune system of successfully treated people living with HIV
(PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell …