Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

LJ Delaney, S Isguven, JR Eisenbrey, NJ Hickok… - Materials …, 2022 - pubs.rsc.org
Administration of drugs through oral and intravenous routes is a mainstay of modern
medicine, but this approach suffers from limitations associated with off-target side effects and …

Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches

M Ashrafizadeh, K Luo, W Zhang, AR Aref… - Environmental research, 2023 - Elsevier
A high number of cancer patients around the world rely on gemcitabine (GEM) for
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …

Landscape of cellular bioeffects triggered by ultrasound-induced sonoporation

D Przystupski, M Ussowicz - International journal of molecular sciences, 2022 - mdpi.com
Sonoporation is the process of transient pore formation in the cell membrane triggered by
ultrasound (US). Numerous studies have provided us with firm evidence that sonoporation …

[HTML][HTML] Focused ultrasound hyperthermia augments release of glioma-derived extracellular vesicles with differential immunomodulatory capacity

ND Sheybani, AJ Batts, AS Mathew, EA Thim… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Increasing evidence points to the critical role of extracellular vesicles (EVs) as
molecular parcels that carry a diverse array of bioactive payloads for coordination of …

The revolutionary roads to study cell–cell interactions in 3d in vitro pancreatic cancer models

D Delle Cave, R Rizzo, B Sainz Jr, G Gigli… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic cancer is an extremely lethal malignancy with a survival rate
lower than any other cancer type. For decades, two-dimensional (2D) cultures have been …

SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?

S Kotopoulis, M Popa, M Mayoral Safont, E Murvold… - Pharmaceutics, 2022 - mdpi.com
The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has
shown great promise in cancer therapy from in vitro to ongoing clinical studies. The fastest …

Stability of engineered micro or nanobubbles for biomedical applications

B Park, S Yoon, Y Choi, J Jang, S Park, J Choi - Pharmaceutics, 2020 - mdpi.com
A micro/nanobubble (MNB) refers to a bubble structure sized in a micrometer or nanometer
scale, in which the core is separated from the external environment and is normally made of …

Low-intensity sonoporation-induced intracellular signalling of pancreatic cancer cells, fibroblasts and endothelial cells

R Haugse, A Langer, ET Murvold, DE Costea… - Pharmaceutics, 2020 - mdpi.com
The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has
great potential to increase the efficacy of chemotherapy. However, the molecular …

Power-Doppler-based NH002 microbubble sonoporation with chemotherapy relieves hypoxia and enhances the efficacy of chemotherapy and immunotherapy for …

SY Wu, CH Wang, ST Kang, CF Yu, FH Chen… - Scientific Reports, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) poses challenges due to late-stage diagnosis
and limited treatment response, often attributed to the hypoxic tumor microenvironment …

Ultrasound-enabled therapeutic delivery and regenerative medicine: Physical and biological perspectives

K Bansal, CK Jha, D Bhatia… - ACS Biomaterials Science …, 2021 - ACS Publications
The role of ultrasound in medicine and biological sciences is expanding rapidly beyond its
use in conventional diagnostic imaging. Numerous studies have reported the effects of …