Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich
Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory …

NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

The most common form of neuropathy associated with diabetes mellitus is distal symmetric
sensorimotor polyneuropathy, often accompanied by autonomic neuropathy. This disorder is …

This review will focus on the impact of hyperglycemia‐induced oxidative stress in the
development of diabetes‐related neural dysfunction. Oxidative stress occurs when the …

Mammalian cells utilize a wide variety of cell volume regulatory mechanisms. For rapid
adjustment of cell volume cells release or accumulate ions through respective channels and …

It is evident from the present analysis that although a role for Ca2+ in controlling hypertonic
cell volume regulation and RVI mechanisms has not been shown, Ca2+ plays a central role …

Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved
in the pathogenesis of diabetic complications. In addition to polyol synthesis, aldose …

Complementary DNA clones encoding human aflatoxin B1 aldehyde reductase (AKR7A2),
aldehyde reductase (AKR1A1), aldose reductase (AKR1B1), dihydrodiol dehydrogenase 1 …

Aldose reductase is the first enzyme of the sorbito!(or polyol) pathway (Fig. 1). Under
physiological conditions, flux through this pathway is probably low in most tissues, but it has …