The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis but also has profound effects on therapeutic efficacy. In the case of …

Prognostication is an integral part of cancer diagnostic and helps oncologists to guide
treatment decisions and therapy intensity. Accumulating evidence suggest that the stroma …

Automatic recognition of different tissue types in histological images is an essential part in
the digital pathology toolbox. Texture analysis is commonly used to address this problem; …

The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic
parameter in colon cancer as well as in other epithelial cancer types, and may be …

Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor–
stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field …

In this study, we investigate a novel in vitro model to mimic heterogeneous breast tumors
without the use of a scaffold while allowing for cell-cell and tumor-fibroblast interactions …

Background Tumour stroma percentage (TSP) has previously been reported to predict
survival in patients with colorectal cancer (CRC); however, whether this is independent of …

The tumour microenvironment consists of a complex mixture of non‐neoplastic cells,
including fibroblasts, immune cells and endothelial cells embedded in the proteins of the …

Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …

In cancer, both histopathologic images and genomic signatures are used for diagnosis,
prognosis, and subtyping. However, combining histopathologic images with genomic data …