Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …

Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …

Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle,
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …

Polyglutamylation is a posttranslational modification that generates glutamate side chains
on tubulins and other proteins. Although this modification has been shown to be reversible …

All microtubules are built from a basic α/β-tubulin building block, yet subpopulations of
microtubules can be differentially marked by a number of post-translational modifications …

Microtubules give rise to intracellular structures with diverse morphologies and dynamics
that are crucial for cell division, motility, and differentiation. They are decorated with …

Microtubules–polymers of tubulin–perform essential functions, including regulation of cell
shape, intracellular transport and cell motility. How microtubules are adapted to perform …

Posttranslational modifications of tubulin are emerging regulators of microtubule functions.
We have shown earlier that upregulated polyglutamylation is linked to rapid degeneration of …