Reciprocal regulation of mesenchymal stem cells and immune responses

Y Wang, J Fang, B Liu, C Shao, Y Shi - Cell stem cell, 2022 - cell.com
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

H Xing, Z Zhang, Q Mao, C Wang, Y Zhou… - Journal of …, 2021 - Springer
Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration
(IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the …

Targeting inflammation to treat diabetic kidney disease: the road to 2030

S Rayego-Mateos, RR Rodrigues-Diez… - Kidney international, 2023 - Elsevier
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases

Z Shen, W Huang, J Liu, J Tian, S Wang… - Frontiers in …, 2021 - frontiersin.org
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …

Mesenchymal stem cells and their microenvironment

J Liu, J Gao, Z Liang, C Gao, Q Niu, F Wu… - Stem Cell Research & …, 2022 - Springer
Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …

[HTML][HTML] Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury

JY Cao, B Wang, TT Tang, Y Wen, ZL Li, ST Feng… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mesenchymal stem cells-derived exosomes (MSC-exos) have attracted great interest as a
cell-free therapy for acute kidney injury (AKI). However, the in vivo biodistribution of MSC …

Treatment with mesenchymal stem cell‐derived nanovesicle‐containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and …

L Pang, H Jin, Z Lu, F Xie, H Shen, X Li… - Advanced …, 2023 - Wiley Online Library
Osteoarthritis is a degenerative disorder that can severely affect joints, and new treatment
strategies are urgently needed. Administration of mesenchymal stem cell (MSC)‐derived …

Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications

P Li, Q Ou, S Shi, C Shao - Cellular & molecular immunology, 2023 - nature.com
Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and play
essential roles in tissue regeneration and homeostasis. MSCs can be isolated from …

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

C Zheng, B Sui, X Zhang, J Hu, J Chen… - Journal of …, 2021 - Wiley Online Library
Apoptosis is a naturally occurring process generating plenty of apoptotic vesicles (apoVs),
but the feature, fate and function of apoVs remain largely unknown. Notably, as an …