[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

S Mirzaei, AT Mohammadi, MH Gholami… - Pharmacological …, 2021 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects

D Hasan Khudhair, AI Al-Gareeb… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the
treatment of different types of cancers and the management of chronic inflammatory …

The influences of ferulic acid on the growth performance, haemato-immunological responses, and immune-related genes of Nile tilapia (Oreochromis niloticus) …

MAO Dawood, AES Metwally, ME El-Sharawy… - Aquaculture, 2020 - Elsevier
The use of food additives is an important preventive approach that has proven to maintain
the health status of fish, especially under stressful conditions. The dietary ferulic acid (FA) …

Ferulic acid ameliorates hepatic inflammation and fibrotic liver injury by inhibiting PTP1B activity and subsequent promoting AMPK phosphorylation

J Wu, X Xue, G Fan, Y Gu, F Zhou, Q Zheng… - Frontiers in …, 2021 - frontiersin.org
Chronic inflammation in response to persistent exogenous stimuli or damage results in liver
fibrosis, which subsequently progresses into malignant liver diseases with high morbidity …

[HTML][HTML] Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating …

X Wang, Y He, J Tian, I Muhammad, M Liu, C Wu… - Ecotoxicology and …, 2021 - Elsevier
Abstract Aflatoxin B1 (AFB1) causes oxidative stress and hepatocyte apoptosis through its
epoxidized metabolite AFBO, which is catalyzed by CYP450 enzymes. Ferulic acid (FA) is a …

Virgin coconut oil: A comprehensive review of antioxidant activity and mechanisms contributed by phenolic compounds

YQ Zeng, JT He, BY Hu, W Li, J Deng… - Critical Reviews in …, 2024 - Taylor & Francis
Virgin coconut oil (VCO) is obtained by processing mature coconut cores with mechanical or
natural methods. In recent years, VCO has been widely used in the food, pharmaceutical …

Protective Effect of Honey and Propolis against Gentamicin‐Induced Oxidative Stress and Hepatorenal Damages

H Laaroussi, M Bakour, D Ousaaid… - Oxidative medicine …, 2021 - Wiley Online Library
Bee products are a promising source of phenolic compounds with strong antioxidant activity.
The present study was designed to explore the protective effect of honey, propolis, and their …

Nutraceutical strategies for suppressing NLRP3 inflammasome activation: pertinence to the management of COVID-19 and beyond

MF McCarty, SB Iloki Assanga, L Lewis Luján… - Nutrients, 2020 - mdpi.com
Inflammasomes are intracellular protein complexes that form in response to a variety of
stress signals and that serve to catalyze the proteolytic conversion of pro-interleukin-1β and …